Which Supplements Interact With Metformin?

• Chromium

  0.3% of the low end at 1 mL
  1 mL, the label dose0.7 mcg

  200-1,000 mcg a day in glucose studies200-1,000 mcg

  Printed on the label: 0.7 mcg per mL. (NIH ODS, Chromium)

• Gymnema

  4.5% of the low end at 1 mL (even split)
  1 mL, the label dose, even split9.1 mg

  1 mL, label-order ceiling (place 8)25 mg

  200-400 mg a day of extract200-400 mg

  Not printed: #8 in a 200 mg blend of 22. (Drugs.com, Gymnema monograph)

• African mango

  3.0% of the low end at 1 mL (even split)
  1 mL, the label dose, even split9.1 mg

  1 mL, label-order ceiling (place 4)50 mg

  300 mg a day (150 mg twice)300 mg

  Not printed: #4 in a 200 mg blend of 22. (NIH ODS, Dietary Supplements for Weight Loss)

• Panax ginseng

  9.1% of the low end at 1 mL (even split)
  1 mL, the label dose, even split9.1 mg

  1 mL, label-order ceiling (place 12)17 mg

  From about 100 mg a day (up to 20 g)100 mg

  Not printed: #12 in a 200 mg blend of 22. (Shishtar et al., PLoS One 2014)

• Green tea

  6.4% of the low end at 1 mL (even split)
  1 mL, the label dose, even split9.1 mg

  1 mL, label-order ceiling (place 7)29 mg

  141-1,207 mg catechins a day141-1,207 mg

  Not printed: #7 in a 200 mg blend of 22. (NIH ODS, Dietary Supplements for Weight Loss)

Red bars: what 1 mL, the label dose, can hold. The label prints just one amount, for chromium; for blend ingredients we show an even split (200 mg / 22, about 9 mg per mL) and the most the label order allows. Gold bars show the daily amount of that one ingredient in studies, and the light extension shows a range. Even the ceilings fall short of the studied doses.